News June 2015
IT'S ALL ABOUT SOLUBILITY
Latest developments in co-crystal formation of APIs, AgroChems and Nutraceuticals
With an increase in the size and complexity of the molecules that enter into development, companies face a larger number of compounds that are either poorly soluble, difficult to crystallize or problematic with respect to desired physicochemical properties for successful development. Over 40% of marketed drugs today have low solubility. In early discovery, 80-90% of drug candidates could fail because of solubility issues. Traditional approaches such as salt formation may no longer offer sufficient opportunities to provide a solution. Co-crystallization has emerged over the past decade as an attractive technique for modification of the physicochemical properties of organic compounds.
Webinar on Discovery of co-crystals! Did you miss this webinar? Click here to view the webinar.
CURRENT TRENDS IN THE LABORATORIES OF GSK, ROCHE, ASTRAZENECA
Crystalline™ - The Instrument for Induction Time Measurements
A 2015 multiauthor review article aiming to bring readers up to date with current trends in the field of process analytical technology appoints the CRYSTALLINE™ as the instrument to be used for induction time measurements (1). The publication is presenting applications both in industrial laboratories and in manufacture e.g. at GSK, AstraZeneca and Roche.
Your OLD Crystal16® Gets NEW Life
Exchange now your old Crystal16® for a new one
Technobis Crystallization Systems is happy to exchange your old Crystal16® for a NEW one at low price.
After more than 8 years of success by more than 200 companies, the Crystal16® is the world's most used equipment for generating solubility curves, phase diagrams, crystallization research, salt formation, co-crystallization, amorphous solid dispersion and process development. The new features in the Crystal16® include:
- New software, flexible, user friendly, and with improved research capabilities.
- Optional overhead stirring capabilities.
- Integrated air-cooling eliminate the need for messy chillers or an in-house water supply.
- Extended temperature range from -15°C to 150°C.