The new industry standard
Efficient determination of solubility curves
Solubility is the foundation piece of information on which any solid-state screening and solid form process is based on. The Crystal16 has been designed from the ground up to provide you with accurate polythermal solubility data faster and easier than traditional methods. By using 16 individual reactors in 4 parallel reactor blocks, the device can quickly generate solvent/antisolvent libraries and give you the solubility and MSZW curves required for your research project.
Using a Crystal16 with 16 vials holding 4 different concentrations of a drug substance in 4 different solvents and applying 2 temperature cycles with a heating rate of 0.5 °C/min and a cooling rate of 1 °C/min, 4 solubility curves can be measured in duplicate in half a day.
Discover why several pharmaceutical companies have already chosen the Crystal16 as their standard tool to determine solubility of their drug compounds.
Solubility data are used to make crucial decisions from the earliest stages of drug discovery and throughout the entire development process. This white paper covers two dynamic methods for effective and reproducible solubility data generation: the temperature variation and solvent addition methods. These methods can be easily applied by making use of the turbidity probes integrated in the Crystal16 and particle viewer cameras of the Crystalline instruments.