Webinar topic
In isolation of a drug substance or its intermediate, either a more stable or a metastable form can be the target polymorph of product. It can be very challenging to ensure robust isolation of pure target form directly from a crystallization process. In this webinar, we present practical methodologies that allow collection of kinetic data to guide effective process design and control for robust isolation of either form of an enantiotropic pair.
Through a case study, we will illustrate how combined assessment of polymorphic conversion kinetics and nucleation kinetics via applications of PAT tool and automation can provide critical data that are difficult to obtain otherwise. Such data indicate proper ranges of critical process parameters and offer direct guidance for rational process design to target either the more stable or the metastable polymorph.
Guest speakers
Diana Camacho Corzo
Senior Research Scientist, J-STAR Research
Dr. Diana Camacho is a Senior Research Scientist in the crystallization process development group at J-Star Research, a Porton Company. As part of this group, she has focused on implementing methodologies for understanding crystallization kinetics at early stages of crystallization process development. Diana earned a Ph.D. in Chemical Engineering from the University of Leeds in the U.K, where she was also a Postdoctoral Researcher implementing modelling tools for crystallization processes design and scale up.
Weiqi Chen
Senior Research Scientist, J-STAR Research
Dr. Weiqi Chen is a Senior Scientist with 2.5 years of experience in early phase crystallization process development in the crystallization group at J-Star Research, a Porton Company. Weiqi specializes in applying process analytical technology (PAT) tools in crystallization process development for enhancing process understanding. He is experienced with automated systems, particle engineering, and scale-up & tech-transfer. Prior to joining J-Star, Weiqi was a Postdoctoral researcher at the University of Delaware. He earned a Ph.D. degree from New York University, a Master of Science degree from the University of Florida, and a Bachelor of Science degree from Nankai University.