Crystallization Monitoring with Raman Spectroscopy

  • Application note
  • July 11, 2019
About the author

Technobis Crystallization Systems is grateful to Dr Manuel Henry, Boehringer Ingelheim Pharma GmbH & Co. KG, for his help with this application note.

Learn more about using real time Raman during crystallization experiments

This application note discusses how to identify polymorphic transformation by using Raman and the Crystalline instrument.

It includes a case study carried out at Boehringer Ingelheim laboratories, which shows both significant and small changes in the crystal structure of an active ingredient. 

Content overview:
  • Crystalline & RAMAN Advantages
  • Learn here how to identify polymorphic transformation by using Raman and the Crystalline instrument
  • Typical RAMAN shifts indicating polymorphic transformations
  • Boehringer Ingelheim Case Study
  • Real Time Raman during Crystallization Experiments

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