Crystallization Screening with the Crystallization Systems Workflow

Every year, hundreds of active ingredients are produced within the pharmaceutical, food, personal care, dye and agrochemical industries. Understanding the solid state of your active ingredient will lead you to full properties acquirement. Polymorphs, as well as solvates or hydrates of your active ingredient may differ in key properties such as solubility, dissolution rate, stability, and particle habit. Finding the optimal form with the best characteristics for development is critical. When the compound reaches the batch-production stage, reproducibility of the desired polymorphic or salt form is of key importance in the development of the compound. In order to be able to select the optimal form, knowledge of as many as possible forms is needed. Crystallization is the experimental technique used to perform solid form screens. 

The CRYSTALLIZATION SYSTEMS WORKFLOW are the perfect tools for crystallization screening at different working volumes. Depending on the amount of material available, now scientists around the world can perform solid form screens at microliter scale with the CrystalBreeder, at 1mL scale with the Crystal16 and at 5mL scale with the Crystalline instruments.

The crystallization space can be systematically explored with the ability to control temperature profiles, stirring speed and crystallization mode. Whether you are searching for new polymorphs, or doing salt or co-crystal screens, the turbidity signal gives you a clear indication of a hit. Several crystallizatione methods are now available: 

  • Cooling crystallization
  • Evaporation crystallization
  • Combined cooling evaporation crystallization
  • Vapor diffusion crystallization
  • Slurry
  • Thermocycling
  • Anti-solvent crystallization

The Crystalline instrument with through the vial analytical capabilities like particle visualization allows you to visualize the crystallization experiments. With the real time particle viewer you know exactly what is happening, when it is happening. By making use of the accurate thermocycling program of the CrystallinePV, you can investigate and control any crystallization process.

Click here to read more about Crystalline PV

Click here to read more about Crystal16

Click here to read more about CrystalBreeder

 

P. Láng et al./ Journal of Pharmaceutical and Biomedical Analysis, 84 (2013) 177– 183
M. Karashimaetal./Journal of Crystal Growth 390(2014), 30–37
Philipp P. Nievergelt and Bernhard Spingler, CrystEngComm, 2017, 19, 142–147