The future of reaction screening is here

  • Press Release
  • March 19, 2024

Technobis launches game-changing reaction screening instrument

World-leading laboratory technology developer Technobis has released ReactALL™, an innovative benchtop multiple reactor system for medium throughput experimentation, helping scientists tap into the under-utilized nights and weekends. Available globally now, ReactALL™ uses novel integrated automated sampling technology to accelerate chemical reaction screening, optimisation, route scouting, reaction profiling and kinetics. The device’s launch cements Technobis’ transition from a developer of crystallization instruments to a pioneer of R&D equipment for the whole research ecosystem.

ReactALL™ addresses the gap between high throughput and low throughput screening to provide high-quality, data rich results with low material needs.

SmartCap™ technology

Technobis’ new instrument, developed with scientific input from Pfizer, uses proprietary SmartCap™ technology to sample, quench and dilute directly into commercial standard HPLC (high performance liquid chromatography) vials. Reaction setup is fast, taking less than 30 minutes with ReactALL™.

The system comprises five small-scale reactors, each equipped with fully automated sampling. Representative samples are immediately quenched, diluted, and transferred to standard HPLC vials on the ReactALL™. The sample and dilution volumes are precisely controlled by the system for quantitative analysis. Wide bore tubing and streamlined pump-free fluidics assure robust sample transfer, even for heterogeneous samples. And the novel SmartCap™ sampling technology does not pierce reactor septa, so there are no pierced holes for losing solvent. The diluted samples are held in HPLC vial racks which are compatible with common HPLCs for easy transfer to the HPLC for a streamlined workflow.

SmartCap™ technology

Assisting chemists in early research decisions

Accelerating in-depth chemical understanding is a key goal of the ReactALL™. Such data-rich experiments can translate to significant time saving, and thus money. Screening reactions for the best reagents, catalysts and conditions; optimising reaction yield, selectivity and impurity control; mechanistic profiling; ReactALL™ obtains high quality results early in drug development to allow chemists to draw the right conclusions, as early as possible.

A guiding ethos at Technobis is ‘Help research succeed’. ReactALL™ will transform the way chemists conduct medium throughput research and in the pharmaceutical industry, which is close to my heart, bring medicines to market faster than ever before. Technobis wants to take its expertise in crystallization R&D equipment further, using our knowledge and experience to enable process chemists to make leaps forward for the whole industry’s benefit. – John de Kok, CEO of Technobis.

Designed by scientists, for scientists

Technobis instruments are designed by scientists, for scientists. ReactALL™ possesses multiple features that enhance reaction scientists’ investigation capabilities. Colour cameras, integrable Raman spectroscopy probes, provide crucial information on physical and chemical state changes, such as dissolution and precipitation, colour changes, and much more. ReactALL™ uses overhead stirring designed specifically with the aid of Computational Fluid Dynamics to closely recreate mixing properties conferred by mechanical agitators, and poorly captured by magnetic stir bars.

Ready for the Lab of the future

It’s essential that ReactALL™ fits into the lab of the future and industry 4.0 compatibility is key there. Our software engineers have enabled interoperability with pretty much anything you might want in your workflow. – Stephan van Banning, CTO at Technobis

For example, ReactALL™ could run reactions and automatically take, quench and dilute samples into HPLC vials. A pre-loaded SmartCap™ could be loaded in ReactALL™ while a robotic arm could then transport your sample vial trays to the HPLC machine. The chemist would need only 30 minutes for setting up the reactions and the next day, they already have the HPLC data.

Streamlining the laboratory workflow

Easy integration into existing workflows is crucial for adoption of any new equipment, so this was a key consideration for Technobis from the first day of development for ReactALL™. Reports from beta testers say clearly that the revolutionary new instrument is user friendly and fits straight into their workflows. The time reclaimed by automating sampling in reaction screening experiments outside of working hours makes ReactALL™ a must have instrument.

As a chemist myself, I understand the transformation that this instrument will bring to laboratories’ workflows. This gap between high throughput and low throughput represents a huge opportunity for industry efficiency improvement. The ability to obtain such data rich results at such an early stage of research, with such small reagent volume requirements, will save significant time and money. – Dr. Carmen Guguta, Global Head of Business Development and Marketing for Technobis.

A big milestone for Technobis

Technobis knows a lot about doing more with less. The company has already achieved world-leading status in the crystallization industry and has set the standard for technological innovation with its track record of success. Now, it wants to bring its deep understanding of R&D instrumentation and end user needs to reaction screening, to serve research with state-of-the-art equipment and that same elite standard.

Technobis sees that automation and interoperability of devices are at the forefront of the wave of change that is sweeping analytical laboratories. It aims to use its vast knowledge and experience to become a thought-leader in process chemistry R&D and support scientists from the first step to last step in the research ecosystem.

More about ReactALL™

To learn more about how ReactALL™ can help your laboratory workflow step into the future, visit the product page.