Content overview
Solubility and nucleation studies are fundamental to crystallization process development. However, these studies are often conducted independently and focused on single compounds or solvents. This leads to fragmented insights and inefficiencies.
The Multi-Analyses feature available for both Crystal16 and Crystalline instruments in the crystallization systems software addresses this gap by enabling users to combine multiple experimental data sets into a single, unified graphical interface. Particularly in nucleation studies, where running 80+ experiments in a single session is difficult, Multi-Analyses enables data to be collected in smaller batches and reliably merged. This powerful tool allows for direct comparison of solubility curves, metastable zone width (MSZW) equations, and nucleation kinetics across various systems.
In this application note, we present a number of case studies where the multi-analyses feature was used to enhance research:
- Case study: Measuring solubility for solvent screening and antisolvent selection
- Case study: Comparing nucleation kinetics of ascorbic acid in various solvent systems
- Case study: Generating solubility and metastable zone width (MSZW) curves specifically for colored compounds
