From Experimentation To Modelling: Understanding The Effect Of Solvent Composition On Solubility
About
Solution crystallization is a necessary unit operation for the separation, purification, and crystal modification in active pharmaceutical ingredient (API) production.
For the discovery of high-end drugs, it becomes challenging to know the solubility varying with several parameters (temperature, solvent, solvent composition) considering the shortage of time and material for some crucial APIs.
In this Application Note, we studied the effect of solvent composition on solubility of ascorbic acid using the Crystal16 instrument.
Content overview:
- Solvent selection in crystallization
- Why predicting solubility is important?
- Case Study: Effect of solvent composition on solubility of ascorbic acid
- Conclusion