Linking Solution Chemistry to Crystallization



Crystallization from solution is widely used to purify and isolate active pharmaceutical ingredients (API). The formation pathway of crystals strongly depends on interactions between solvent molecules and molecules of the API. As a result, solution chemistry influences the final properties of the crystalline API such as particle shape, size and polymorphism.

Using analytical techniques, the ordering of molecules in solution can be experimentally measured and linked to the crystalline form. Furthermore, research into the early stages of crystal nucleation can be predicted using nucleation kinetics obtained from induction time measurements. Together, these approaches have provided insight into the roles of desolvation and molecular self-assembly in the crystallization of organic molecules. 

This webinar will present examples in which solution-phase measurements as well as nucleation kinetics can be used to elucidate how molecules in solution become large ordered crystalline structures. The role of solvent choice in the crystallization of the blockbuster drug Pregabalin will be presented in detail. 

This webinar is open to researchers interested in crystallization, looking to solve day to day crystallization challenges and optimize their best practices.

 

Biography Dr René Steendam

Dr René Steendam obtained his Master and PhD in synthetic organic chemistry and crystallization at the Radboud University (Netherlands) on the topic of chiral resolution. He received a Rubicon fellowship to develop continuous chiral resolution processes at the University of Strathclyde (UK). After that, René worked at the university of Limerick (Ireland) on the topic of crystal nucleation. Currently, René works as a project leader on crystallization at Ardena.



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