Polymer screening for amorphous solid dispersions (ASDs) using the Crystal16

  • Crystallization
  • 2 October 2025, Online

About

Amorphous solid dispersions (ASDs) are advanced pharmaceutical formulations in which a poorly water-soluble drug is dispersed within an amorphous polymer matrix. In this non-crystalline form, the drug exhibits enhanced apparent solubility. While various polymers can be considered, the optimal polymer must effectively maintain supersaturation by inhibiting drug crystallization.

In this webinar, we demonstrate the application of the solvent shift method [i] as a preliminary screening tool to reduce the number of polymers selected for further evaluation. Piroxicam, a BCS Class II non steroidal anti-inflammatory drug (NSAID) with low aqueous solubility, was used as the model compound. The use of the Crystal16 system in screening polymers for piroxicam with the solvent shift method will be discussed in detail.

[i] International Journal of Pharmaceutics Volume 419, Issues 1–2, 31 October 2011, Pages 170-174

Date: Thursday, 2 October 2025
Time: 4.00 pm CET | 10.00 am EDT |  7.00 am PDT | 7.30 pm IST

Guest speaker

Thierry Bonnaud

Principal Scientist - Solid Form and Particle Engineering at Veranova

Thierry Bonnaud has a background in organic synthesis and drug discovery and over 27 years of experience in the industry. He worked at the Neuroscience Centre of Pfizer in 1999 in Cambridge (UK) then in 2000 joined the combinatorial chemistry group of Medivir (Cambridge, UK) where he was involved in the synthesis of new enzyme inhibitors.

He joined Pharmorphix® part of SAFC Pharma (Cambridge, UK) in 2007 and has continued to work at the site which today serves as the global centre of excellence for Solid Form and Particle Engineering at Veranova, a global CDMO. During this time, he has had several roles of increasing seniority spanning project and technical leadership. His technical interests and acumen span  salt, polymorphism and cocrystal studies including chiral separation. He is the co-author of a review on cocrystals and co-authors of over 20 patent applications.