The Crystalline PV/RR gives the user access to real time Raman spectroscopy, in combination with a sophisticated parallel crystallizer with turbidity measurement. The independent Raman probes are integrated in an ergonomically designed, pre-aligned, robust and sealed module. The user does not have to insert any probes into the reaction vessel.
Traditionally analytical techniques are implemented in an off-line fashion, where samples have to be removed from the reaction or process, in order to obtain information about chemical composition or interactions. With offline techniques one obtains information on a few data points in time, but the nagging question always remains: Have I missed something? With the Crystalline PV/RR it is easy to follow crystallization processes and to study polymorph conversions, hydration or the formation of solvates in slurries.
Chemical interactions like co-crystal and salt formation can be studied effortlessly during the process. This hassle-free tool enables you to screen many solvents, counter-ions or co-formers on a small amount of compound – giving you valuable answers much earlier on in the process and in short time.
Real time information on chemical interactions
Drive reactions based on spectroscopic results
Measure relative reaction rates
Raman spectrum transformation for carbamazepine captured using the Tornado HyperFlux integrated with the Crystalline PV/RR